Evaluation of the genotoxic potential of dimethyl sulfoxide (DMSO) in meristematic cells of the root of Vicia faba
作者： Rafael Valencia-Quintana , Sandra Gómez-Arroyo , Stefan Marian Waliszewski , Juana Sánchez-Alarcón , José Luis Gómez-Olivares
DOI: 10.1007/S13530-012-0130-9
关键词:
摘要: Dimethyl sulfoxide (DMSO) is an organic solvent with several biological applications. It extensively used to dissolve compounds that hardly in water detect their genotoxic activity vitro. In this study DMSO will be tested determine its potential. The effect of on the frequency chromosomal aberrations anaphase as well DNA fragmentation through comet assay has been evaluated meristematic cells root tips Vicia faba. observed increases when concentration increases, reaching maximum value 20% and decreasing at 30 40% DMSO, comparison value, but significantly higher than values control. Similarly, percentage damage index showed same behavior; some possible mechanisms action are discussed.
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