Comparison of upper-limb and lower-limb exercise training in patients with intermittent claudication.

摘要: To investigate the effects of a 24-week programme upper- and lower-limb aerobic exercise training on walking performance quality life in patients with symptomatic peripheral arterial disease (PAD) to study mechanisms, which could influence improvement. Following approval from North Sheffield Local Research Ethics Committee, 104 (median age 69 y, range 50-85 y) stable PAD were randomised into an or group, nonexercise control group. Training was performed twice weekly for 24-weeks at equivalent relative intensities. An incremental arm- leg-crank test (ACT LCT, respectively) maximum tolerance before 6-, 12-, 18- intervention determine peak oxygen consumption (VO[2]). Walking performance, defined as claudication distance (CD MWD achieved intolerable pain, assessed same time-points using shuttle-walk protocol. Peak blood lactate concentration, ratings perceived exertion (Borg RPE) pain CR-10) recorded during all assessments. Physical activity status, community-based ability throughout period. Assessments repeated 24- 48-weeks following Both CD increased over time (P <0.01) both groups.At 24-weeks, had improved by 56% 65% 30% 35% upper-limb groups, respectively. These changes associated improvements distance, speed stair-climbing <0.01). All assigned exhibited increase LCT VO[2] time-point relation baseline measures <0.01), whereas ACT only group <0.05). concentration (1.95 +/- 0.14 vs. 2.40 +/-0.17 mM, mean SEM; P <0.05) amount experienced observed This suggests that alteration accounted, least part, improvement this Upon completing period general health status groups However, physical functioning bodily energy vitality At follow-up, remained 39% 48% 18% 26%(P respectively, compared measures. A retained confidence also observed, however global trained patient returned baseline. can be useful modalities improving cardiovascular function, PAD. combination physiological adaptations altered might account through indicates although measures, progressive dwindling Reluctance continuation home-setting observed.