Alpha-Tocopherol Supplementation in Healthy Individuals Reduces Low-Density Lipoprotein Oxidation but Not Atherosclerosis

摘要: Background— Epidemiological studies have demonstrated an inverse relationship between vitamin E intake and cardiovascular disease (CVD) risk. In contrast, randomized controlled trials reported conflicting results as to whether supplementation reduces atherosclerosis progression CVD events. Methods Results— The study population consisted of men women ≥40 years old with LDL cholesterol level ≥3.37 mmol/L (130 mg/dL) no clinical signs or symptoms CVD. Eligible participants were DL-α-tocopherol 400 IU per day placebo followed every 3 months for average years. primary trial end point was the rate change in common carotid artery far-wall intima-media thickness (IMT) assessed by computer image-processed B-mode ultrasonograms. A mixed effects model using all determinations IMT used test hypothesis treatment differences rates. Compared placebo, α-tocopherol significantly raised plasma vi...