Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits.

摘要: The purpose of this research was to prepare acyclovir niosomes in a trial improve its poor and variable oral bioavailability. nonionic surfactant vesicles were prepared by the conventional thin film hydration method. lipid mixture consisted cholesterol, span 60, dicetyl phosphate molar ratio 65:60:5, respectively. percentage entrapment ∼11% used process. have an average size 0.95 µm, most probable 0.8 range 0.4 2.2 µm. Most unilamellar spherical shape. In vitro drug release profile found follow Higuchi’s equation for free niosomal drug. formulation exhibited significantly retarded compared with vivo study revealed that dispersion improved bioavailability rabbits after single dose 40 mg kg−1. relative from relation solution 2.55 indicating more than 2-fold increase showed significant mean residence time (MRT) reflecting sustained characteristics. conclusion, could be promising delivery system prolonged profiles.