Formulation and characterization of drug loaded nonionic surfactant vesicles (niosomes) for oral bioavailability enhancement.

摘要: Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability tenofovir disoproxil fumarate (TDF), anti-HIV drug. Niosomes by conventional thin film hydration technique different molar ratios surfactant, cholesterol, and dicetyl phosphate. The niosomes found spherical in shape, ranging from 2.95 μm to 10.91 μm size. Vesicles 1 : 1 : 0.1 surfactant : cholesterol : dicetyl phosphate each grade span have higher entrapment efficiencies, which further selected for vitro vivo studies. sorbitan monostearate maximum drug release (99.091%) at end 24 hours followed zero order kinetics. results study revealed that significantly enhanced TDF rats after a dose 95 mg/kg. average relative relation plane solution was be 2.58, indicating more than twofold increase TDF. Significant mean residential time (MRT) also found, reflecting retarding efficacy vesicles. In conclusion, could promising delivery improved prolonged profiles.