Bi-phasic expression of Heterochromatin Protein 1 (HP1) during breast cancer progression: Potential roles of HP1 and chromatin structure in tumorigenesis.

摘要: Epigenetics in cancer prognosis and therapy is gaining recognition recent years. Breast a genetic disease harboring numerous mutations, including tumor suppressor BRCA1 BRCA2 mutations. However, the functions of cells are also altered by non-genetic mechanisms, DNA methylation chromatin structure. Therefore, identification epigenetic markers for breast very important early diagnosis effective therapy. This review focuses on findings roles Heterochromatin protein 1 (HP1) progression. We previously showed that function progression frequently associated with HP1 expression level potentially Herein, we suggest bi-phasic during indicates dual tumorigenesis. Exploiting differential tumors could lead to Re-setting structure may be critical step high-efficiency many patients.