Downregulation of HP1α suppresses proliferation of cholangiocarcinoma by restoring SFRP1 expression
作者： Wenlong Cheng , Li Tian , Bing Wang , Yongqiang Qi , Wenhua Huang
DOI: 10.18632/ONCOTARGET.10371
关键词: DNA methylation 、 Gene 、 Heterochromatin 、 Immunology 、 Gene silencing 、 Cell growth 、 Downregulation and upregulation 、 Cell biology 、 Transfection 、 Cell culture 、 Medicine
摘要: Heterochromatin protein 1α (HP1α) is a gene that mediates chromatin conformation, silencing and cancer progression. However, little known regarding the impact of HP1α in pathogenesis cholangiocarcinoma (CCA). In present study, we demonstrate significantly upregulated CCA tissues cell lines, while downregulation leads to suppression proliferation. Then find can decrease H3K9me3 enrichment DNA methylation rate secreted frizzled-related 1 (SFRP1) promoter, resulting restoring expression SFRP1. Moreover, restoration SFRP1 suppress cells These results provide mechanistic understanding role may offer novel therapeutic target this disease.
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