Evaluation of hydrogels for bio-printing applications.

作者: Sean V. Murphy , Aleksander Skardal , Anthony Atala

DOI: 10.1002/JBM.A.34326

关键词:

摘要: In the United States alone, there are approximately 500,000 burn injuries that require medical treatment every year. Limitations of current treatments necessitate development new methods can be applied quicker, result in faster wound regeneration, and yield skin is cosmetically similar to undamaged skin. The hydrogel biomaterials bioprinting deposition technologies has provided a platform address this need. Herein we evaluated characteristics twelve hydrogels determine their suitability for applications. We chose either commercially available, or commonly used research purposes. specific properties relevant applications, specifically; gelation time, swelling contraction, stability, biocompatibility printability. Further, described regulatory, commercial financial aspects each hydrogels. While many screened may exhibit suitable other UV-crosslinked Extracel, hyaluronic acid-based hydrogel, had desired our application. Taken together with availability, shelf life, potential regulatory approval ease use, these materials hold further developed into fast effective healing treatments.

参考文章(59)
Michael Michener, Blake C. Rodgers, Michael S. Williams, Emillia C. O. Lloyd, Outpatient burns: prevention and care. American Family Physician. ,vol. 85, pp. 25- 32 ,(2012)
Gabor Forgacs, Karoly Jakab, Anatolij Kachurin, Brook Damon, Adrian Neagu, Three-dimensional tissue constructs built by bioprinting. Biorheology. ,vol. 43, pp. 509- 513 ,(2006)
Aleksander Skardal, Jianxing Zhang, Lindsi McCoard, Xiaoyu Xu, Siam Oottamasathien, Glenn D. Prestwich, Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting Tissue Engineering Part A. ,vol. 16, pp. 2675- 2685 ,(2010) , 10.1089/TEN.TEA.2009.0798
Cyrille Norotte, Francois S. Marga, Laura E. Niklason, Gabor Forgacs, Scaffold-free vascular tissue engineering using bioprinting. Biomaterials. ,vol. 30, pp. 5910- 5917 ,(2009) , 10.1016/J.BIOMATERIALS.2009.06.034
Kuen Yong Lee, David J. Mooney, ALGINATE: PROPERTIES AND BIOMEDICAL APPLICATIONS Progress in Polymer Science. ,vol. 37, pp. 106- 126 ,(2012) , 10.1016/J.PROGPOLYMSCI.2011.06.003
Robert Chang, Jae Nam, Wei Sun, Direct Cell Writing of 3D Microorgan for In Vitro Pharmacokinetic Model Tissue Engineering Part C-methods. ,vol. 14, pp. 157- 166 ,(2008) , 10.1089/TEN.TEC.2007.0392
Jason A. Burdick, Glenn D. Prestwich, Hyaluronic Acid Hydrogels for Biomedical Applications Advanced Materials. ,vol. 23, ,(2011) , 10.1002/ADMA.201003963
Jeroen D. Boogaarts, J. André Grotenhuis, Ronald H.M.A. Bartels, Tjemme Beems, Use of a novel absorbable hydrogel for augmentation of dural repair: results of a preliminary clinical study. Neurosurgery. ,vol. 57, pp. 146- 151 ,(2005) , 10.1227/01.NEU.0000164384.05351.59