Heart Failure : from Hippocrates and Harvey to molecular biology

摘要: The understanding of heart, failure has progressed in all but a linear fashion. many false starts (due to understand pathophysiology) led therapeutic strategies that have subsequently been abandoned; these range from bloodletting-based on the belief heart is source body's heat-to use inotropic drugs, which reflected more recent view major problem this syndrome depressed contractility. current focus beneficial and deleterious features cardiac enlargement may be durable because it returned our attention maladaptive hypertrophy, whose role determining prognosis had recognized during 19th century, today supported by new discoveries cell signaling molecular biology.