Premature luteinization: could it be an early manifestation of low ovarian reserve?

摘要: Abstract Objective: To gain insight into the physiologic significance of premature luteinization and to evaluate whether it could be a manifestation low ovarian reserve. Design: Retrospective evaluation. Setting: Reproductive medicine unit. Patient(s): Thirty-one consecutively seen women with normal ovulation unexplained infertility. Intervention(s): Induction superovulation hMG coupled synchronized IUI. A GnRH agonist was not used during study. Main Outcome Measure(s): Premature defined as progesterone/estradiol ratio >1 on day hCG administration. Patients were evaluated their first cycles treatment then divided those (study group) without (control luteinization. The reserve parameters compared between two groups. Result(s): Nineteen 31 patients infertility demonstrated Patient characteristics similar study control Mean (±SD) 3 FSH levels 8.2 ± 3.3 6.6 1.7 mIU/mL in groups, respectively. estradiol significantly higher than group (74 49 pg/mL vs. 30 17 pg/mL, respectively). administration also differed groups (760 539 1,568 675 Likewise, number follicles that ≥15 mm lower (2.9 1.5 4.3 1.3, total dose duration clinical pregnancy rates after four 15.8% 41.7% Conclusion(s): This preliminary work suggests that, are treated agonist, signs an early It appears this uncover pathogenesis