Regulation of HIV-1 gene expression by the transactivator protein Tat.

摘要: The regulation of HIV-1 gene expression is an area intense investigation. Like all retroviruses, integrates into cellular DNA, and its dependent on host cell transcription factors polymerases (Gaynor 1992). Cellular are able to interact with distinct regulatory regions in the long terminal repeat modulate In addition, viral-encoded proteins critical control expression. A number important questions exist concerning mechanisms which regulate What responsible for increases response T-lymphocyte activation? that repress quiescent cells? How do transactivator stimulate expression? An understanding these determining interplay between viral