Endogenous ROS levels in C. elegans under exogenous stress support revision of oxidative stress theory of life-history tradeoffs

摘要: The oxidative stress theory of life-history tradeoffs states that caused by damaging free radicals directly underpins between reproduction and longevity altering the allocation energetic resources these tasks. We test this characterizing effects exogenous insult its interaction with thermal diet quality on a suite traits correlations in Caenorhabditis elegans nematodes. also quantify demographic aging rates endogenous reactive oxygen species (ROS) levels live animals. Our findings indicate tradeoff investment antioxidant defense (somatic maintenance) consistent theoretical predictions, but standard yield little evidence generates strict tradeoffs. Increasing insult, however, shows strong tendency to uncouple positive phenotypic and, particular, reduce correlation lifespan. found mild results lower ROS accompanied hormetic changes lifespan, aging, disappear combined-stress treatments--consistent aging. demonstrate is direct contributor trait variation traditional are not necessary invoke as mediator relationships traits, supporting previous calls for revisions theory.