Forty years of progress in the study of the hydrogen bond

摘要: The author looks back at developments over the last few decades concerning H–bond. list of atoms involved as proton donor and acceptor has broadened dramatically, including most electronegative even metals. factors that control transfer across H–bond have been elucidated show importance minor changes in its geometry. Small stretches can shut down entirely, certain bends force a to against pK gradient. Along with recognition CH..O interaction represent true H–bond, one strength comparable more traditional H–bonds, come an understanding contributions protein structure function. replacement bridging H by any litany leads similarly strong interactions, many features virtually indistinguishable from These noncovalent interactions are typically referred halogen, chalcogen, pnicogen, tetrel bonds, depending upon identity substitute atom.