In vitro model systems to study androgen receptor signaling in prostate cancer

摘要: Prostate cancer (PCa) is one of the most common causes male cancer-related death in Western nations. The cellular response to androgens mediated via androgen receptor (AR), a ligand-inducible transcription factor whose dysregulation plays key role during PCa development and progression following deprivation therapy, current mainstay systemic treatment for advanced PCa. Thus, better understanding AR signaling new strategies abrogate activity are essential improved therapeutic intervention. Consequently, large number experimental cell culture models have been established facilitate vitro investigations into progression. These different model systems mimic distinct stages this heterogeneous disease exhibit differences with respect expression/status responsiveness. Technological advances facilitated that more closely reflect physiological setting, example use three-dimensional coculture study interaction prostate epithelial cells stroma, endothelium, immune system tissue matrix environment. This review provides an overview commonly used currently available particular focus on their addressing questions relating It hoped continued will provide biologically relevant platforms mechanistic studies, drug discovery design ensuring rapid transfer knowledge from laboratory clinic. Key Words " castration-resistant stroma tumor