Polymorphism of the Soluble Epoxide Hydrolase Is Associated With Coronary Artery Calcification in African-American Subjects. The Coronary Artery Risk Development In Young Adults (CARDIA) Study

摘要: Background— Modulation of endogenous epoxide levels by soluble hydrolase (sEH) in the endothelium represents an important mechanism regulation cardiovascular function. We examined relationship between a common, functional polymorphism human sEH gene and coronary artery calcification (CAC) young, largely asymptomatic African-American non-Hispanic white subjects. Methods Results— Multiple logistic regression Tobit models were used to assess Arg287Gln presence quantity CAC. Models adjusting for race (except race-specific analyses), age, sex, smoking, body mass index, systolic blood pressure, LDL cholesterol, HDL cholesterol estimated. Allele genotype frequency distributions not significantly different 2 ethnic groups (P=0.22; P=0.17, respectively). The was significant predictor CAC status participants, ...