Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives
作者： Kothanahally S. Sharath Kumar , Ananda Hanumappa , Maruthai Vetrivel , Mahesh Hegde , Yarabhally R. Girish
DOI: 10.1016/J.BMCL.2015.06.069
关键词:
摘要: 4-Thiazolidinone derivatives were synthesized using T3P (R)-DMSO media as a cyclodehydrating agent. All the molecules tested for their cytotoxicity against leukemic cell lines. The compound 3-(4-bromophenyl)-2-(4-(dimethylamino)phenyl)thiazolidin-4-one (4e) with electron donating substituent at para position of phenyl ring displayed considerable Reh and Nalm6 cells an IC50 value 11.9 13.5 mu M, respectively. Furthermore, 4e tumor regression studies induced by EAC in Swiss albino mouse. Both vitro vivo results suggested significant antiproliferative activity mouse tissue treated showed multifocal areas necrosis numerous number apoptotic cells. (C) 2015 Elsevier Ltd. rights reserved.
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