Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications
作者： Umberto Mura , Sandro Cosconati , Luciana Marinelli , Ettore Novellino , Stefania Sartini
DOI: 10.1016/J.EJMECH.2011.03.068
关键词:
摘要: In continuing the search for more effective 5-arylidene-4-thiazolidinones as aldose reductase inhibitors, a new set of suitably substituted compounds (4, 5 and 8) was explored. Acetic acids 5, particularly 5a 5h, proved to be interesting inhibitors enzyme well excellent antioxidant agents that are potentially able counteract oxidative stress associated with both diabetic complications other pathologies. Molecular docking experiments supported SAR studies.
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