Human Cancer-Associated Antigens: Present Status and Implications for Immunodiagnosis

摘要: Publisher Summary The successful demonstration of specific antigens in animal tumors essentially provided a major impetus to the search for comparable human neoplasms. This chapter examines considerable amount data that have accumulated recent years on tumor-associated (TAAs) solid assess their specificity and possible usefulness early diagnosis cancer. selection material included is arbitrary, as there an absence clear-cut universally accepted definition TAA. TAAs are extremely heterogeneous group molecules overlap with normal so great it practically impossible define such way distinguish them clearly from ordinary cellular components. considers molecule TAA if its presence renders cancer cell quantitatively or qualitatively different counterpart. appear be oncofetal digerentiation apparent due generally increased concentration tumor cells.