Association between a TGFBR2 Gene Polymorphism (rs2228048, Asn389Asn) and Acute Rejection in Korean Kidney Transplantation Recipients
作者： Yeong-Hoon Kim , Tae Hee Kim , Sun Woo Kang , Hyun Ju Kim , Seok Ju Park
DOI: 10.3109/08820139.2013.777073
关键词:
摘要: Transforming growth factor-β (TGF-β) signaling transduction initiates TGF-β activation, resulting in activation of receptor II (TGFBR2). Any quantitative and qualitative changes TGFBR2 are expected to affect the pathway, which occupies a central position with respect regulation cell growth, differentiation, apoptosis, immune reaction, angiogenesis extracellular matrix formation. Recent studies have shown that TGF-β1 gene polymorphisms may confer susceptibility early acute chronic allograft rejection kidney transplantation recipients. In this study, we assessed whether were associated rejection. A total 347 renal recipients transplanted at three centers Korea analyzed. Three SNPs (rs764522, rs3087465, rs2228048) genotyped from genomic DNA direct sequencing. Multiple logistic regression models (codominant, dominant, recessive, l...
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