Transforming growth factor-β1 in mothers’ colostrum and immune responses to cows’ milk proteins in infants with cows’ milk allergy

摘要: Abstract Background: Breast milk contains immune factors that compensate for the underdeveloped defenses of gut newborn infant. Objective: We sought to study importance these in responses infants with cows' allergy (CMA) proteins (CM). Methods: prospectively followed development CMA 6209 healthy and collected samples colostrum from mothers. Samples mothers control subjects were analyzed immunoglobulins, CM-specific antibodies, cytokines. In CMA, correlations between concentration transforming growth factor (TGF)-β1 extent response CM studied. Results: The TGF-β1 IgE-mediated (n = 65) was lower (mean, 589 pg/mL; 95% confidence interval [CI], 413-840) than non-IgE–mediated 37; mean, 1162 CI, 881-1531; t 2.57, P .012). 126 mean 807 pg/mL (95% 677-963). 96-100), positively correlated IgA antibodies β-lactoglobulin IgG α-casein whole formula negatively diameter a skin prick test lymphocyte stimulation indices β-lactoglobulin. Conclusions: an infant prone having content mother's may promote IgG-IgA antibody production inhibit IgE- cell-mediated reactions CM. (J Allergy Clin Immunol 1999;104:1093-8.)