Methods and reagents for decreasing clinical reaction to allergy

摘要: It has been determined that allergens, which are characterized by both humoral (IgE) and cellular (T cell) binding sites, can be modified to less allergenic modifying the IgE sites. The sites converted non-IgE masking site with a compound prevents or altering as little single amino acid within protein, most typically hydrophobic residue towards center of IgE-binding epitope, eliminate binding. method allows protein altered minimally possible, other than-within while retaining ability activate T cells, and, in some embodiments not significantly decreasing IgG capacity examples use peanut allergens demonstrate alteration critical acids each epitopes important immunoglobulin have determined. Substitution even led loss Although shared no common sequence motif, residues located epitope appeared