Ménière's Disease and Autoimmunity

摘要: Identifying the etiopathogenesis of MtniBre’s disease (MD) has been object several studies since Prosper MCnikre first described main symptoms this in 1861 : fluctuating hearing loss, vertigo, and tinnitus. Endolymphatic hydrops is considered pathological finding associated with MD a good deal research directed toward identification understanding its underlying mechanisms. Because sensory neural elements inner ear cannot be visualized their diseased state vivo, diagnosis based mainly on evaluation clinical results audiological tests. Since Rask-Andersen Stahle’ recognized as having an immunological function, authors have added support to idea multifactorial origin by hypothesizing possible role system pathogenesis. In fact, 1983 Shea autoimmune mechanisms patients typical who responded favorably steroid treatment or plasmapheresis.* Immunohistochemical also revealed presence reaction within inner-ear tissues, such stria vascularis, supporting connective tissues blood vessels, only small number inve~tigated.~-~ Although these are certainly affected technical problems linked tissue preservation processing, they still suggestive that certain types caused factors ear. Immune comparatively new area research, over time different reactions led introduction laboratory tests patients. The pathogenetic disorders seem due either type 2 cytotoxic interaction autoantibodies tissue-bond antigen type-3 IgGand IgM-mediated creates circulating immune complexes. generic mechanism inducing damage specific T-cell clonal expansion, autoantibody formation, complement cascade activation inflammatory cell recruitment. Inner-ear resultant could depend upon well anatomical site involved reaction, which critical determining endolymphatic hydrops. One issues factor triggers Tand B-lymphocytes production against structure