Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.
作者： Linda M. Pak , Nancy E. Kemeny , Marinela Capanu , Joanne F. Chou , Taryn Boucher
DOI: 10.1002/JSO.24898
关键词:
摘要: Background/objectives Combination hepatic artery infusion (HAI) and systemic (SYS) chemotherapy for unresectable CRLM results in high tumor-response rates. This study represents an update of long-term survival conversion to resectability patients with treated HAI SYS a phase II study. Method The primary endpoint was complete resection. Multivariate landmark analysis assessed the effect resection on progression-free (PFS) overall (OS). Results From 2007 2012, 64 median 13 tumors were enrolled; 67% had prior chemotherapy. 33 (52%) converted Median follow-up among survivors 81 months. PFS OS 38 months, respectively, 5-year-OS 36%. Chemotherapy-naive 51%. Conversion only independent factor prognostic improved OS. Nine (14%) are NED (five since initial resection, three after recurrent disease, one from alone) at 86 months treatment initiation, 72 last operative intervention. Conclusion is effective therapy high-volume CRLM, resulting rate survival, potential cure.
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