Increased severity of chemically induced seizures in mice with partially deleted Vitamin D receptor gene
作者： Allan V. Kalueff , Anna Minasyan , Tiina Keisala , Marianne Kuuslahti , Susanna Miettinen
DOI: 10.1016/J.NEULET.2005.10.007
关键词:
摘要: Vitamin D is a neuroactive steroid hormone with multiple functions in the brain. Numerous clinical and experimental data link various D-related dysfunctions to epilepsy. Here, we study role of receptors (VDRs) epilepsy mice. To examine this problem, assessed seizure profiles VDR knockout mice following systemic injection pentylenetetrazole (70 mg/kg). Overall, compared wild-type (WT) 129S1 (n = 10 each group), group significantly demonstrated shorter latencies onset, higher Racine scores increased mortality rates. Our findings suggest that VDRs modulate susceptibility mice, D/VDR endocrine system may be involved pathogenesis © 2005 Elsevier Ireland Ltd. All rights reserved.
elsevier.com
sci-hub.se 参考文章(48)
D. Feldman, S. Carswell, Vitamin D in the nervous system: actions and therapeutic potential. Vitamin D.. pp. 1197- 1211 ,(1997)
A. V. Kalueff, K. O. Eremin, P. Tuohimaa, Mechanisms of Neuroprotective Action of Vitamin D 3 Biochemistry. ,vol. 69, pp. 738- 741 ,(2004) , 10.1023/B:BIRY.0000040196.65686.2F
Wayne N. Frankel, Laura Taylor, Barbara Beyer, Bruce L. Tempel, H.Steve White, Electroconvulsive thresholds of inbred mouse strains. Genomics. ,vol. 74, pp. 306- 312 ,(2001) , 10.1006/GENO.2001.6564
Thi-Minh Nguyen, Michèle Lieberherr, Janine Fritsch, Huguette Guillozo, Maria Laura Alvarez, Zohra Fitouri, Frederic Jehan, Michèle Garabédian, The rapid effects of 1,25-dihydroxyvitamin D3 require the vitamin D receptor and influence 24-hydroxylase activity: studies in human skin fibroblasts bearing vitamin D receptor mutations. Journal of Biological Chemistry. ,vol. 279, pp. 7591- 7597 ,(2004) , 10.1074/JBC.M309517200
Shigeaki Kato, Tatsuya Yoshizazawa, Sachiko Kitanaka, Akiko Murayama, Ken-ichi Takeyama, Molecular genetics of vitamin D- dependent hereditary rickets. Hormone Research in Paediatrics. ,vol. 57, pp. 73- 78 ,(2002) , 10.1159/000057955
B Xu, B Michalski, R.J Racine, M Fahnestock, Continuous infusion of neurotrophin-3 triggers sprouting, decreases the levels of TrkA and TrkC, and inhibits epileptogenesis and activity-dependent axonal growth in adult rats. Neuroscience. ,vol. 115, pp. 1295- 1308 ,(2002) , 10.1016/S0306-4522(02)00384-6
Alison M. Pack, Martha J. Morrell, Epilepsy and bone health in adults. Epilepsy & Behavior. ,vol. 5, pp. 24- 29 ,(2004) , 10.1016/J.YEBEH.2003.11.029
C. Leranth, C.E. Ribak, Calcium-binding proteins are concentrated in the CA2 field of the monkey hippocampus: a possible key to this region's resistance to epileptic damage. Experimental Brain Research. ,vol. 85, pp. 129- 136 ,(1991) , 10.1007/BF00229993
F Feron, THJ Burne, J Brown, E Smith, JJ McGrath, A Mackay-Sim, DW Eyles, Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Research Bulletin. ,vol. 65, pp. 141- 148 ,(2005) , 10.1016/J.BRAINRESBULL.2004.12.007
L. P. Zanello, A. W. Norman, Rapid modulation of osteoblast ion channel responses by 1α,25(OH)2-vitamin D3 requires the presence of a functional vitamin D nuclear receptor Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 1589- 1594 ,(2004) , 10.1073/PNAS.0305802101