Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model
作者： Aeri Shim , Jae-Hyoung Song , Bo-Eun Kwon , Jeong-Jun Lee , Jae-Hee Ahn
DOI: 10.1038/SREP23110
关键词:
摘要: Human rhinovirus (HRV) is the most common viral infectious agent in humans and predominant cause of cold. There a need for appropriate vaccines or therapeutic agents to treat HRV infection. In this study, we investigated whether itraconazole (ICZ) can protect cells from HRV-induced cytotoxicity. Replication HRV1B was reduced by ICZ treatment lungs HRV1B- as compared vehicle-treated mice. The numbers immune cells, including granulocytes monocytes, were bronchoalveolar lavage fluid (BALF) administration after infection, corresponding decreased pro-inflammatory cytokine chemokine levels BALF. A histological analysis lung tissue showed that suppressed inflammation caused Interestingly, pretreatment mice with form nasal spray had potent prophylactic antiviral activity. Cholesterol accumulation plasma membrane observed upon infection; blocked cholesterol trafficking membrane, well resulted its subcellular compartments near nucleus. These findings suggest potential which be adopted preventatively therapeutically.
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