Aging and the Regulation of Hormones: A View in October 1974

摘要: The last ten years of research have shown a number significant changes in hormonal regulation during aging. For example, there is virtually complete halt estrogen production by the ovary after menopause (1); contrast, such change does not occur males (2, 3; and Table 1). adrenal cortex In men shows substantial decreases Cortisol (4) pregnanediol (5). Specific age-related cell activities recently been associated with altered levels hormones, as atrophy vaginal uterine epithelium humans (6) rodents (7) reproductive senescence. Changes liver enzyme observed aging this author (8), Adelman (9), others (10) may also be attributed to hormone regulation. Because well established effect steroid hormones (11), T3 (12), pituitary (13) on nuclei, many other are, doubtlessly, consequences hormones.