Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

摘要: Alternative processing of the RNA transcribed from calcitonin gene appears to result in production a messenger neural tissue distinct that thyroidal ‘C’ cells. The thyroid mRNA encodes precursor hormone whereas tissues generates novel neuropeptide, referred as gene-related peptide (CGRP). distribution CGRP-producing cells and pathways brain other suggests functions for nociception, ingestive behaviour modulation autonomic endocrine systems. approach described here permits application recombinant DNA technology analyses complex neurobiological systems absence prior structural or biological information.