The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention.
作者： John P Alao
关键词:
摘要: Cyclin D1 is an important regulator of cell cycle progression and can function as a transcriptionl co-regulator. The overexpression cyclin has been linked to the development cancer. Deregulated degradation appears be responsible for increased levels in several cancers. Recent findings have identified novel mechanisms involved regulation stability. A number therapeutic agents shown induce degradation. ablation may useful prevention treatment In this review, current knowledge on discussed. Novel insights into are also discussed context ablative therapy. unresolved questions regarding cellular addressed.
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