Landscape of Cyclin Pathway Genomic Alterations Across 5,356 Prostate Cancers: Implications for Targeted Therapeutics
作者： Razelle Kurzrock , Sherri Z. Millis , Siraj M. Ali , Denis L. Jardim , Jeffrey S. Ross
DOI: 10.1002/ONCO.13694
关键词:
摘要: The cyclin pathway may confer resistance to standard treatments but also offer novel therapeutic opportunities in prostate cancer. Herein, we analyzed cancer samples (majority metastatic) using comprehensive genomic profiling performed by next-generation sequencing (315 genes, >500× coverage) for alterations activating and sensitizing genes (CDK4 amplification, CDK6 CCND1, CCND2, CCND3, CDKN2B [loss], CDKN2A SMARCB1), androgen receptor (AR) gene, coalterations leading inhibitor (RB1 CCNE1). Overall, abnormalities were found 9.7% of the 5,356 tumors. Frequent included CCND1 amplification (4.2%) B loss (2.4% each). Alterations possible RB1 CCNE1, detected (up 54.6% neuroendocrine) 1.2% cases, respectively, whereas AR seen 20.9% tumors (~27.3% anaplastic). Cyclin more frequently associated with concomitant alterations.
sci-hub.st 参考文章(14)
Dan Robinson, Eliezer M Van Allen, Yi-Mi Wu, Nikolaus Schultz, Robert J Lonigro, Juan-Miguel Mosquera, Bruce Montgomery, Mary-Ellen Taplin, Colin C Pritchard, Gerhardt Attard, Himisha Beltran, Wassim Abida, Robert K Bradley, Jake Vinson, Xuhong Cao, Pankaj Vats, Lakshmi P Kunju, Maha Hussain, Felix Y Feng, Scott A Tomlins, Kathleen A Cooney, David C Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E Rathkopf, Michael J Morris, Stephen B Solomon, Jeremy C Durack, Victor E Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T Lis, Michaela Bowden, Stephen P Balk, Glenn Gaviola, Carrie Sougnez, Manaswi Gupta, Y Yu Evan, Elahe A Mostaghel, Heather H Cheng, Hyojeong Mulcahy, Lawrence D True, Stephen R Plymate, Heidi Dvinge, Roberta Ferraldeschi, Penny Flohr, Susana Miranda, Zafeiris Zafeiriou, Nina Tunariu, Joaquin Mateo, Raquel Perez-Lopez, Francesca Demichelis, Brian D Robinson, Marc Schiffman, David M Nanus, Scott T Tagawa, Alexandros Sigaras, Kenneth W Eng, Olivier Elemento, Andrea Sboner, Elisabeth I Heath, Howard I Scher, Kenneth J Pienta, Philip Kantoff, Johann S De Bono, Mark A Rubin, Peter S Nelson, Levi A Garraway, Charles L Sawyers, Arul M Chinnaiyan, None, Integrative clinical genomics of advanced prostate cancer Cell. ,vol. 161, pp. 1215- 1228 ,(2015) , 10.1016/J.CELL.2015.05.001
Youyuan Xu, Shao-Yong Chen, Kenneth N. Ross, Steven P. Balk, Androgens Induce Prostate Cancer Cell Proliferation through Mammalian Target of Rapamycin Activation and Post-transcriptional Increases in Cyclin D Proteins Cancer Research. ,vol. 66, pp. 7783- 7792 ,(2006) , 10.1158/0008-5472.CAN-05-4472
Melissa Fazzari, Carlos Cordon-Cardo, Marija Drobnjak, Howard I. Scher, Iman Osman, Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone. Clinical Cancer Research. ,vol. 6, pp. 1891- 1895 ,(2000)
Teresa Helsten, Shumei Kato, Maria Schwaederle, Brett N. Tomson, Timon P.H. Buys, Sheryl K. Elkin, Jennifer L. Carter, Razelle Kurzrock, Cell-Cycle Gene Alterations in 4,864 Tumors Analyzed by Next-Generation Sequencing: Implications for Targeted Therapeutics Molecular Cancer Therapeutics. ,vol. 15, pp. 1682- 1690 ,(2016) , 10.1158/1535-7163.MCT-16-0071
James P. Stice, Suzanne E. Wardell, John D. Norris, Alexander P. Yllanes, Holly M. Alley, Victoria O. Haney, Hannah S. White, Rachid Safi, Peter S. Winter, Kimberly J. Cocce, Rigel J. Kishton, Scott A. Lawrence, Jay C. Strum, Donald P. McDonnell, CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC. Molecular Cancer Research. ,vol. 15, pp. 660- 669 ,(2017) , 10.1158/1541-7786.MCR-17-0028
Joshua Armenia, , Stephanie A. M. Wankowicz, David Liu, Jianjiong Gao, Ritika Kundra, Ed Reznik, Walid K. Chatila, Debyani Chakravarty, G. Celine Han, Ilsa Coleman, Bruce Montgomery, Colin Pritchard, Colm Morrissey, Christopher E. Barbieri, Himisha Beltran, Andrea Sboner, Zafeiris Zafeiriou, Susana Miranda, Craig M. Bielski, Alexander V. Penson, Charlotte Tolonen, Franklin W. Huang, Dan Robinson, Yi Mi Wu, Robert Lonigro, Levi A. Garraway, Francesca Demichelis, Philip W. Kantoff, Mary-Ellen Taplin, Wassim Abida, Barry S. Taylor, Howard I. Scher, Peter S. Nelson, Johann S. de Bono, Mark A. Rubin, Charles L. Sawyers, Arul M. Chinnaiyan, Nikolaus Schultz, Eliezer M. Van Allen, The long tail of oncogenic drivers in prostate cancer Nature Genetics. ,vol. 50, pp. 645- 651 ,(2018) , 10.1038/S41588-018-0078-Z
Alexandra M. Blee, Yundong He, Yinhui Yang, Zhenqing Ye, Yuqian Yan, Yunqian Pan, Tao Ma, Joseph Dugdale, Emily Kuehn, Manish Kohli, Rafael Jimenez, Yu Chen, Wanhai Xu, Liguo Wang, Haojie Huang, TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53-Mutated Prostate Cancer. Clinical Cancer Research. ,vol. 24, pp. 4551- 4565 ,(2018) , 10.1158/1078-0432.CCR-18-0653
David A Quigley, Ha X Dang, Shuang G Zhao, Paul Lloyd, Rahul Aggarwal, Joshi J Alumkal, Adam Foye, Vishal Kothari, Marc D Perry, Adina M Bailey, Denise Playdle, Travis J Barnard, Li Zhang, Jin Zhang, Jack F Youngren, Marcin P Cieslik, Abhijit Parolia, Tomasz M Beer, George Thomas, Kim N Chi, Martin Gleave, Nathan A Lack, Amina Zoubeidi, Robert E Reiter, Matthew B Rettig, Owen Witte, Charles J Ryan, Lawrence Fong, Won Kim, Terence Friedlander, Jonathan Chou, Haolong Li, Rajdeep Das, Hui Li, Ruhollah Moussavi-Baygi, Hani Goodarzi, Luke A Gilbert, Primo N Lara, Christopher P Evans, Theodore C Goldstein, Joshua M Stuart, Scott A Tomlins, Daniel E Spratt, R Keira Cheetham, Donavan T Cheng, Kyle Farh, Julian S Gehring, Jörg Hakenberg, Arnold Liao, Philip G Febbo, John Shon, Brad Sickler, Serafim Batzoglou, Karen E Knudsen, Housheng H He, Jiaoti Huang, Alexander W Wyatt, Scott M Dehm, Alan Ashworth, Arul M Chinnaiyan, Christopher A Maher, Eric J Small, Felix Y Feng, None, Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. ,vol. 174, pp. 889- 889 ,(2018) , 10.1016/J.CELL.2018.06.039
Sadakatsu Ikeda, Sheryl K. Elkin, Brett N. Tomson, Jennifer L. Carter, Razelle Kurzrock, Next-generation sequencing of prostate cancer: genomic and pathway alterations, potential actionability patterns, and relative rate of use of clinical-grade testing Cancer Biology & Therapy. ,vol. 20, pp. 219- 226 ,(2019) , 10.1080/15384047.2018.1523849
Kamal Pandey, Hee‐Jung An, Seung Ki Kim, Seung Ah Lee, Sewha Kim, Sun Min Lim, Gun Min Kim, Joohyuk Sohn, Yong Wha Moon, Molecular mechanisms of resistance to CDK4/6 inhibitors in breast cancer: A review International Journal of Cancer. ,vol. 145, pp. 1179- 1188 ,(2019) , 10.1002/IJC.32020