Overexpression of cyclin D1 is associated with metastatic prostate cancer to bone.

摘要: Cyclin D1 is a key regulator of the G1 phase progression cell cycle. There increasing evidence that deregulated cyclin expression implicated in tumorigenesis and tumor certain neoplasms. Recently, it has been reported overexpression might be related to evolution androgen-independent disease prostate cancer. This study was conducted investigate patterns cancer samples representing different points natural history treatment disease. Association with clinical outcomes also explored. Using immunohistochemistry, 86 radical prostatectomy specimens (53 naive 33 after androgen deprivation) 22 bone metastases were studied. We examined difference primary versus metastatic cases. In addition, we association cases between clinicopathological parameters poor outcome, including time prostate-specific antigen relapse Ki67 proliferative index. D1-positive phenotype, defined as identification positive immunoreactivity nuclei > or =20% cells, observed 10 (11%) compared 15 (68%) (P = 0.001). no correlation either Gleason score, neo-adjuvant hormone treatment, statistical high index, cells 0.02). These data support hypothesis may represent an oncogenic event bone.