Mediators of reprogramming: transcription factors and transitions through mitosis.
作者： Dieter Egli , Garrett Birkhoff , Kevin Eggan
DOI: 10.1038/NRM2439
关键词:
摘要: It is thought that most cell types of the human body share same genetic information as contained in zygote from which they originate. Consistent with this view, animal cloning studies demonstrated intact genome a differentiated can be reprogrammed to support development an entire organism and allow production pluripotent stem cells. Recent progress reprogramming research now points important role for transcription factors establishment maintenance cellular phenotypes, division mediator transitions between different states gene expression.
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