Autoimmune Encephalitis in Postpartum Psychosis
作者： Veerle Bergink , Thaís Armangue , Maarten J. Titulaer , Sander Markx , Josep Dalmau
DOI: 10.1176/APPI.AJP.2015.14101332
关键词:
摘要: Objective:Significant immunological alterations have been observed in women with first-onset affective psychosis during the postpartum period. Recent studies highlighted possibility that a subset of patients severe psychiatric episodes might suffer from undiagnosed autoimmune encephalitis. Therefore, authors performed three-step immunohistochemistry-based screening for CNS autoantibodies large cohort and matched comparison subjects.Method:Ninety-six consecutive 64 healthy were included. Screening antibodies patient serum was using immunohistochemistry. Samples showing any staining further examined by immunocytochemistry live hippocampal neurons cell-based assays to test anti-N-methyl-d-aspartate (NMDA) receptor antibodies. Cell-based all other known antigens those samples l...
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