Females of HbAS genotype have reduced concentration of the malaria protective deoxyhemoglobin S than males.

摘要: The quantity of the intra-erythrocytic deoxyhemoglobin S (Hb S) affects level protection against malaria and also sickling phenomenon. This study reports on significantly lower concentration Hb in females than males. Data came from 350 children, aged 12–47 months who participated a phase 2b vaccine trial. Hemoglobinopathy G6PD deficiency typing was necessary to ascertain equal representation these protective traits across cohorts. Hemoglobin types (HbAA, HbAS) % were evaluated by HPLC. Alpha thalassemia (alpha-thal) genotypes PCR. overall prevalence for HbAS 20%, 46% 3 alpha genes 10% 2 14% A-. More HbAS/αα/αα genotype had low males mean 37.5% ± 5.4 SD, compared 42.0% 2.5 SD same (P = 0.018). Consistent with reduction females, parasite load nearly twice that but difference not statistically significant. X-chromosome linked did influence S. We conclude that, explains resultant higher load. speculate could explain observations suggesting phenomenon tends be less severe