Gender-Specific Aspects of Pediatric Hematology and Oncology

摘要: Publisher Summary While normal developmental changes in fetal and postnatal hematopoiesis are identical males females, gender-related differences red blood cell production noted adolescence persist throughout adult life. Iron deficiency anemia is particularly common adolescent girls. Although white platelet counts do not differ between coagulation factor levels normally identical, certain disorders of neutrophil function clotting such as chronic granulomatous disease hemophilia X-linked therefore occur overwhelmingly males. Sickle affects females equally but morbidity appears to be increased Childhood cancer more than hematological cancers acute lymphoblastic leukemia non-Hodgkin's lymphoma. Gender survival patterns late effects reported for diagnoses. An appreciation gender-specific aspects hematologic oncologic childhood has resulted the application risk-adapted therapeutic strategies, raises questions about gender susceptibility treatment response. More research required understand molecular pharmacogenetic basis these differences.