Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin.
作者： L H Wexler , M P Andrich , D Venzon , S L Berg , L Weaver-McClure
DOI: 10.1200/JCO.1996.14.2.362
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摘要: PURPOSEWe conducted an open-label, randomized trial to determine whether ICRF-187 would reduce doxorubicin-induced cardiotoxicity in pediatric sarcoma patients.METHODSThirty-eight patients were receive doxorubicin-containing chemotherapy (given as intravenous bolus) with or without ICRF-187. Resting left ventricular ejection fraction (LVEF) was monitored serially multigated radionuclide angiography (MUGA) scan. The two groups compared for incidence and degree of cardiotoxicity, response rates four cycles chemotherapy, event-free overall survival, severity noncardiac toxicities.RESULTSEighteen ICRF-187-treated 15 control assessable cardiac toxicity. less likely develop subclinical (22% v 67%, P < .01), had a smaller decline LVEF per 100 mg/m2 doxorubicin (1.0 2.7 percentage points, = .02), received higher median cumulative dose (410 310 mg/m2, <...
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