One-week quadruple therapy is an effective salvage regimen for Helicobacter pylori infection in patients after failure of standard triple therapy.

摘要: Standard triple therapy remains an important option for eradicating Helicobacter pylori (Hp) in developing countries because of its relatively low cost. However, salvage therapies after failure this regimen remain undefined. The authors therefore investigate the efficacy 1-week quadruple as a second-line treatment Hp infection standard therapy. Seventy-eight patients who failed eradication using 2-week bismuth-based were enrolled and received course (lansoprazole, 30 mg twice daily; bismuth subcitrate, 120 four times clarithromycin, 500 amoxicillin, 1,000 daily) regimen. status was reassessed 7 weeks cessation Among 78 patients, achieved 65 (83%, 95% confidence interval = 75-91%) by intention-to-treat analysis. Only five (6%) had side effects, all (100%) showed good drug compliance. Multivariate analysis disclosed that coffee drinking independent factor (odds ratio 5.3, 1.2-23.6, p 0.028). conclude their is effective population examined. benefits include high rate, short duration treatment, fewer Coffee consumption possibly rescue mechanisms underlying association between require further research.