Helicobacter pylori infection and the risk of gastric malignancy.
作者： Ping-I Hsu , Kwok-Hung Lai , Ping-Ning Hsu , Gin-Ho Lo , Hsien-Chung Yu
DOI: 10.1111/J.1572-0241.2006.01109.X
关键词:
摘要: OBJECTIVE: This prospective cohort study investigated the impact of Helicobacter pylori infection on development various gastric malignancies. METHODS: We prospectively followed up 1,225 dyspeptic Taiwanese who had nonulcer dyspepsia, ulcers, or duodenal ulcers at enrollment. Among them, 618 (50.4%) H. and 607 (49.6%) did not. Patients underwent endoscopy enrollment 1- to 3-yr intervals thereafter. RESULTS: During a mean follow-up 6.3 yr, adenocarcinoma developed in 7 pylori-infected patients, but none uninfected patients (1.1% vs 0.0%, P = 0.015). The incidence lymphoma was 0.2% (1/618) 0% patients. Taken together, rate malignancy significantly higher than that (1.3% 0%, 0.007). subjects, similar between those receiving not eradication therapy (1.4% 1.2%). Multivariate analysis showed intestinal metaplasia only independent factor predicting subsequent subjects with an odds ratio 4.5 (95% Cl 1.1-19.1). CONCLUSIONS: In this study, all malignancies, including lymphoma, finding implies is necessary cause most Follow-up for have indicated.
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