Dietary Glutamine Enhances Murine T-Lymphocyte Responsiveness

摘要: To examine the effects of dietary glutamine on lymphocyte function, male mice aged 6 wk were fed for 2 one three isonitrogenous, isocaloric diets, which varied in concentration. The control diet included 200 g casein/kg, providing 19.6 glutamine/kg; glutamine-enriched provided 54.8 glutamine/kg partly at expense casein; and alanine + glycine-enriched 13.3 glutamine/kg. plasma concentrations a number amino acids because fed. glycine concentration was greater (380 +/- 22 micromol/L) than (177 17 or (115 18 diets. (945 117 those enriched with (561 127 micromol/L), but not different from that (791 35 micromol/L). There significant linear relationship between amount (r = 0.655, P 0.015). Plasma unaffected by diet. reason lack effect increasing upon its circulation may relate to use liver. Thymidine incorporation (56 kBq/well versus <10 kBq/well), expression alpha-subunit interleukin-2 receptor (62 30% positive cells) production [189 28 106 5 (control) 61 13 (alanine enriched) ng/L] concanavalin A-stimulated spleen lymphocytes compared other two Thus, murine enhances ability T respond mitogenic stimulation. Taken together, these observations suggest oral availability could promote T-cell driven, cell-mediated immune response.