Inverse-electron-demand Diels-Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells
作者： Rüdiger Pipkorn , Waldemar Waldeck , Bernd Didinger , Mario Koch , Gabriele Mueller
DOI: 10.1002/PSC.1108
关键词:
摘要: Hormone-refractory prostate cancer (HRPC), insensitive to most cytostatic interventions, features low response rates and bad prognosis. Studies with HRPC treated temozolomide (TMZ) showed a poor the results were discouraging. Therefore, TMZ has been considered be ineffective for treatment of patients symptomatic progressive HRPC. A solution this problem is demonstrated in study by combining proper solid-phase peptide synthesis chemoselective new 'click' chemistry based on Diels-Alder reaction 'inverse-electron-demand' (DAR(inv)) construction highly efficient TMZ-BioShuttle which ligated transporter subcellular address molecules. The transport targeted nuclei resulted much higher efficiency better pharmacological effects. reformulation achieved vitro killing cells. Accordingly, potential tumors was dramatically enhanced even tenfold lower concentration than applied normally. This may well suited chemotherapy other agents or radiation therapy.
sci-hub.se 参考文章(46)
L W Seymour, Passive tumor targeting of soluble macromolecules and drug conjugates. Critical Reviews in Therapeutic Drug Carrier Systems. ,vol. 9, pp. 135- 187 ,(1992)
Mary Shannon Moore, Eric D. Schwoebel, Nuclear import in digitonin-permeabilized cells. Current protocols in pharmacology. ,vol. 5, ,(2000) , 10.1002/0471143030.CB1107S05
Stefan Heckl, Heike Corban-Wilhelm, Rüdiger Pipkorn, Herbert Spring, Waldemar Waldeck, Jürgen Debus, Jürgen Jenne, Klaus Braun, Claus-W. von der Lieth, Intracellular visualization of prostate cancer using magnetic resonance imaging. Cancer Research. ,vol. 63, pp. 4766- 4772 ,(2003)
S.J. Advani, R.R. Weichselbaum, R.J. Whitley, B. Roizman, Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications Clinical Microbiology and Infection. ,vol. 8, pp. 551- 563 ,(2002) , 10.1046/J.1469-0691.2002.00432.X
C J Tabin, J W Hoffmann, S P Goff, R A Weinberg, Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene. Molecular and Cellular Biology. ,vol. 2, pp. 426- 436 ,(1982) , 10.1128/MCB.2.4.426
F MARCHESI, M TURRIZIANI, G TORTORELLI, G AVVISATI, F TORINO, L DEVECCHIS, Triazene compounds: mechanism of action and related DNA repair systems. Pharmacological Research. ,vol. 56, pp. 275- 287 ,(2007) , 10.1016/J.PHRS.2007.08.003
T. LAMBERT, M. RECHT, L. A. VALENTINO, J. S. POWELL, C. UDATA, S. T. SULLIVAN, D. A. ROTH, Reformulated BeneFix®: efficacy and safety in previously treated patients with moderately severe to severe haemophilia B Haemophilia. ,vol. 13, pp. 233- 243 ,(2007) , 10.1111/J.1365-2516.2007.01458.X
Anna Riccardi, Giorgio Mazzarella, Graziella Cefalo, Maria Luisa Garr�, Maura Massimino, Carlo Barone, Alessandro Sandri, Vita Ridola, Antonio Ruggiero, Stefano Mastrangelo, Ilaria lazzareschi, Massimo Caldarelli, Giulio Maira, Enrico Madon, Riccardo Riccardi, Pharmacokinetics of temozolomide given three times a day in pediatric and adult patients Cancer Chemotherapy and Pharmacology. ,vol. 52, pp. 459- 464 ,(2003) , 10.1007/S00280-003-0677-X
Thomas Merdan, Jindrich Kopec̆ek, Thomas Kissel, Prospects for cationic polymers in gene and oligonucleotide therapy against cancer Advanced Drug Delivery Reviews. ,vol. 54, pp. 715- 758 ,(2002) , 10.1016/S0169-409X(02)00046-7
Jennifer L. H. Johnson, Samuel H. Yalkowsky, Reformulation of a new vancomycin analog: An example of the importance of buffer species and strength AAPS PharmSciTech. ,vol. 7, pp. E33- E37 ,(2006) , 10.1208/PT070105