Direct and Indirect Effectiveness and Safety of Pneumococcal Conjugate Vaccine in Practice

摘要: This chapter reviews both the direct and indirect effects of introduction pneumococcal conjugate vaccine into routine use. At this time, available data on impact are primarily from United States, reflecting timing introduction. Reports several sources indicate that use had a profound effect invasive disease (such as bacteremia, bacteremic pneumonia, meningitis) in children occurred quickly following The shortages between 2001 2004 meant many received an abbreviated two-dose series, primary three-dose series without fourth (booster) dose, or experienced delays scheduled administration doses. Pneumococci generally transmitted persons carrying pneumococci nasopharynx to others who become carriers; small percentage new carriers will go develop disease. reduction carriage serotypes have means fewer serotype circulating among families, day care centers, community. Conjugate vaccines currently designed can protect against only limited number 90 serotypes. Data added wealth information top learned clinical trials.