Relationships between serum adiponectin, leptin concentrations and bone mineral density, and bone biochemical markers in Chinese women.

摘要: Abstract Background Adiponectin and leptin, as the main circulating peptides secreted by adipose tissue, are potential contributors to bone metabolism. However, their association with mineral density (BMD) is unknown. We investigated whether these serum adipocytokines concentrations associated BMD turnover markers. Methods Serum adiponectin, leptin concentrations, biochemical markers, were determined in 265 premenopausal 336 postmenopausal Chinese women. Results In women, multiple linear stepwise regression analysis showed that year since menopause, lean mass, estradiol, but not fat independent predictors of adiponectin was predictor BMD. The significant positive correlations between bone-specific alkaline phosphatase (BAP), cross-linked N-telopeptides type I collagen (NTX) found only BAP, NTX, decreased response alendronate therapy. Conclusions an BMD, positively correlated markers It suggested may exert a negative effect on mass promoting excessive resorption loss. effects be mediated menopausal status.