Non-coding RNA/microRNA-modulatory dietary factors and natural products for improved cancer therapy and prevention: Alkaloids, organosulfur compounds, aliphatic carboxylic acids and water-soluble vitamins.
作者： Bernhard Biersack
DOI: 10.1016/J.NCRNA.2016.09.001
关键词:
摘要: Non-coding small RNA molecules, the microRNAs (miRNAs), contribute decisively to epigenetic regulation processes in cancer cells. Problematic pathogenic properties of cells and response cancers towards anticancer drugs are highly influenced by miRNAs. Both increased drug activity formation tumor resistance regulated Further this, survival proliferation metastases is based on modulated expression certain In particular, drug-resistant stem-like (CSCs) depend presence absence specific Fortunately, several molecule natural compounds were discovered that target miRNAs involved modulation aggressiveness resistance. This review gives an overview effects a selection naturally occurring molecules (alkaloids, organosulfur compounds, aliphatic carboxylic acids water-soluble vitamins) closely tangled with diseases.
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