Urea transport in the kidney.

摘要: Urea transport proteins were initially proposed to exist in the kidney late 1980s when studies of urea permeability revealed values excess those predicted by simple lipid-phase diffusion and paracellular transport. Less than a decade later, first transporter was cloned. Currently, SLC14A family transporters contains two major subgroups: SLC14A1, UT-B originally isolated from erythrocytes; SLC14A2, UT-A group with six distinct isoforms described date. In kidney, UT-A1 UT-A3 are found inner medullary collecting duct; UT-A2 is located thin descending limb, primarily vasa recta; all glycoproteins. These crucial kidney's ability concentrate urine. acutely regulated vasopressin. has also been shown be hypertonicity, angiotensin II, oxytocin. Acute regulation these through phosphorylation. Both rapidly accumulate plasma membrane response stimulation vasopressin or hypertonicity. Long-term involves altering protein abundance changes hydration status, low diets, adrenal steroids, sustained diuresis, antidiuresis. have studied using animal models disease including diabetes mellitus, lithium intoxication, hypertension, nephrotoxic drug responses. Exciting new being developed study search for active transporters. Here we introduce describe current knowledge proteins, their regulation, role kidney.