作者: Victor Dzau , Eugene Braunwald
DOI: 10.1016/0002-8703(91)90694-D
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摘要: Advances in cardiovascular research during the past two decades have resulted an improved understanding of chain events that lead to end-stage coronary artery disease. These developments been paralleled by therapeutic advances now make it possible intervene at virtually every stage development advanced cardiac disease, from asymptomatic persons risk developing atherosclerosis patients with heart failure. By interrupting this events, perhaps multiple sites, may be prevent or slow symptomatic disease and hopefully prolong life. Many opportunities exist for obtaining further information regarding underlying pathophysiology, fundamental mechanisms action interventions designed and/or treat myocardial ischemia failure effecting favorably natural history various forms