Order-Restricted Tests for Stratified Comparisons of Binomial Proportions

摘要: The data set presented relates a binomial response to ordered levels of an explanatory variable, representing doses drug, with collected at several centers. A study goal is test independence the and ordinal factor, assuming under alternative only that parameter monotonically increasing function predictor. We present two likelihood-ratio tests are sensitive order-restricted alternatives. Simulating exact distributions statistics yields nearly P-values. also discuss related analyses for comparing groups on response, we propose stochastic ordering alternative.