Stroma-Free Human Hemoglobin A Decreases R3230Ac Rat Mammary Adenocarcinoma Blood Flow and Oxygen Partial Pressure

摘要: We examined the effect of a nitric oxide (NO) quencher, stroma-free human hemoglobin A ( ${\rm HbA}_{0}$; 0.01, 0.05, 0.1, 0.2 g/kg), on blood flow measured using Doppler technique, tumor oxygen pressure $p{\rm O}_{2}$) and diameter arterioles R3230Ac mammary adenocarcinoma as model. In female Fischer 344 rats with 1-cm-diameter tumors implanted in lateral aspect left quadriceps, intravenous infusion 0.1 g/kg HbA}_{0}$ decreased both central peripheral by 20-30% (P < 0.05). Tumor O}_{2}$ 28% HbA}_{0}$, from 15 mm Hg (baseline) to 11 at 10 min = 0.02). Although increased 55% quadriceps muscle proximal 0.05), had little right no implanted, O}_{2}$, 21 23 at...