Plasma amino acid dysregulation after lentiviral infection.
作者： WULF DRÖGE , KRISHNA K. MURTHY , CHRISTIANE STAHL-HENNIG , SUSANNE HARTUNG , ROLAND PLESKER
关键词:
摘要: The absence of AIDS-like symptoms in HIV-infected chimpanzees and SIV-infected African Green monkeys (AGMs) may provide important clues about the pathogenic mechanism AIDS mechanisms resistance. persons rhesus macaques have, on average, markedly decreased cysteine, cystine, glutathione levels elevated plasma glutamate concentrations. Glutamate inhibits membrane transport cystine a combination low high was found to be correlated with CD4+ T cell numbers even HIV-negative healthy human individuals. We have now that are also chimpanzees. But infection chimpanzees, AGMs, goats HIV-1, SIV, caprine arthritis encephalitis virus (CAEV), respectively, does not induce significant changes or levels, although infected AGMs significantly biochemically related amino acid proline.
liebertonline.com参考文章(10)
R G Zanoni, I M Nauta, U Pauli, E Peterhans, Expression in Escherichia coli and sequencing of the coding region for the capsid protein of Dutch maedi-visna virus strain ZZV 1050: application of recombinant protein in enzyme-linked immunosorbent assay for the detection of caprine and ovine lentiviruses. Journal of Clinical Microbiology. ,vol. 29, pp. 1290- 1294 ,(1991) , 10.1128/JCM.29.7.1290-1294.1991
P N Fultz, H M McClure, R B Swenson, C R McGrath, A Brodie, J P Getchell, F C Jensen, D C Anderson, J R Broderson, D P Francis, Persistent infection of chimpanzees with human T-lymphotropic virus type III/lymphadenopathy-associated virus: a potential model for acquired immunodeficiency syndrome. Journal of Virology. ,vol. 58, pp. 116- 124 ,(1986) , 10.1128/JVI.58.1.116-124.1986
P L Nara, W G Robey, L O Arthur, D M Asher, A V Wolff, C J Gibbs, D C Gajdusek, P J Fischinger, Persistent infection of chimpanzees with human immunodeficiency virus: serological responses and properties of reisolated viruses. Journal of Virology. ,vol. 61, pp. 3173- 3180 ,(1987) , 10.1128/JVI.61.10.3173-3180.1987
H.-P. Eck, W. Droge, C. Stahl-Hennig, G. Hunsmann, Metabolic disorder as early consequence of simian immunodeficiency virus infection in rhesus macaques. The Lancet. ,vol. 338, pp. 346- 347 ,(1991) , 10.1016/0140-6736(91)90482-5
S. G. Norley, G. Kraus, J. Ennen, J. Bonilla, H. Konig, R. Kurth, Immunological studies of the basis for the apathogenicity of simian immunodeficiency virus from African green monkeys. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9067- 9071 ,(1990) , 10.1073/PNAS.87.22.9067
H. Alter, J. Eichberg, H Masur, W. Saxinger, R Gallo, A. Macher, H. Lane, A. Fauci, Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS Science. ,vol. 226, pp. 549- 552 ,(1984) , 10.1126/SCIENCE.6093251
W. Dröge, H.-P. Eck, S. Mihm, HIV-induced cysteine deficiency and T-cell dysfunction — a rationale for treatment with N-acetylcysteine Immunology Today. ,vol. 13, pp. 211- 214 ,(1992) , 10.1016/0167-5699(92)90156-2
Hans-Peter Eck, Thomas Mertens, Heinrich Rosokat, Gerd Fätkenheuer, Christoph Pohl, Matthias Schrappe, Volker Daniel, Helmut Näher, Detlef Petzoldt, Peter Drings, Wulf Dröge, T4+ cell numbers are correlated with plasma glutamate and cystine levels: association of hyperglutamataemia with immunodeficiency in diseases with different aetiologies International Immunology. ,vol. 4, pp. 7- 13 ,(1992) , 10.1093/INTIMM/4.1.7
F.J.T Staal, S.W Ela, M Roederer, M.T Anderson, L.A Herzenberg, L.A Herzenberg, Glutathione deficiency and human immunodeficiency virus infection. The Lancet. ,vol. 339, pp. 909- 912 ,(1992) , 10.1016/0140-6736(92)90939-Z
P. W. Berman, J. E. Groopman, T. Gregory, P. R. Clapham, R. A. Weiss, R. Ferriani, L. Riddle, C. Shimasaki, C. Lucas, L. A. Lasky, Human immunodeficiency virus type 1 challenge of chimpanzees immunized with recombinant envelope glycoprotein gp120. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 5200- 5204 ,(1988) , 10.1073/PNAS.85.14.5200