Do women possess a unique susceptibility to the neurotoxic effects of alcohol

摘要: Neurodegeneration and neurological impairment associated with alcohol dependence have been observed predominantly in alcohol-dependent men. Thus little research has examined the neuropathological consequences of alcoholism women. Recent evidence obtained from both human animal studies, however, suggests that women may well be at greater risk alcohol-induced brain injury than men are. Further, researchers used models to identify molecular events contribute this putative sex difference. Such data are likely significance understanding women's unique susceptibility neurotoxic effects addressing possibility medical management require distinct approaches. As a whole, these findings clearly indicate need for significant expansion clinical basic science topic.