Homocysteine as a predictive biomarker in early diagnosis of renal failure susceptibility and prognostic diagnosis for end stages renal disease.
作者： Hatem K. Amin , Mohamed-I Kotb El-Sayed , Ola F. Leheta
DOI: 10.1080/0886022X.2016.1209382
关键词:
摘要: AbstractGlomerular filtration rate and/or creatinine are not accurate methods for renal failure prediction. This study tested homocysteine (Hcy) as a predictive and prognostic marker end stage disease (ESRD). In total, 176 subjects were recruited divided into: healthy normal group (108 subjects); mild-to-moderate impaired function (21 patients); severe (7 chronic (40 patients) who on regular hemodialysis. Blood samples collected, serum was separated analysis of total Hcy, creatinine, high sensitive C-reactive protein (CRP), albumin, calcium. Data showed that Hcy level significantly increased from normal-to-mild impairment then decreases mild until the patient reaches while showing significant elevation in last disease. Creatinine all stages kidney comparison with control....
sci-hub.se 参考文章(50)
J D Finkelstein, J J Martin, Methionine metabolism in mammals. Distribution of homocysteine between competing pathways. Journal of Biological Chemistry. ,vol. 259, pp. 9508- 9513 ,(1984) , 10.1016/S0021-9258(17)42728-1
Darren Thompson, Mark B Pepys, Steve P Wood, The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure. ,vol. 7, pp. 169- 177 ,(1999) , 10.1016/S0969-2126(99)80023-9
Ellen K. Hoogeveen, Pieter J. Kostense, Pieter J. Beks, Albert J. C. Mackaay, Cornelis Jakobs, Lex M. Bouter, Robert J. Heine, Coen D. A. Stehouwer, Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 18, pp. 133- 138 ,(1998) , 10.1161/01.ATV.18.1.133
Koichi Kokame, Hisao Kato, Toshiyuki Miyata, Homocysteine-respondent Genes in Vascular Endothelial Cells Identified by Differential Display Analysis Journal of Biological Chemistry. ,vol. 271, pp. 29659- 29665 ,(1996) , 10.1074/JBC.271.47.29659
Hirokazu Honda, Abdul Rashid Qureshi, Olof Heimbürger, Peter Barany, Kai Wang, Roberto Pecoits-Filho, Peter Stenvinkel, Bengt Lindholm, Serum Albumin, C-Reactive Protein, Interleukin 6, and Fetuin A as Predictors of Malnutrition, Cardiovascular Disease, and Mortality in Patients With ESRD American Journal of Kidney Diseases. ,vol. 47, pp. 139- 148 ,(2006) , 10.1053/J.AJKD.2005.09.014
Takeshi Nakanishi, Yoshinaga Otaki, Yukiko Hasuike, Masayoshi Nanami, Reiko Itahana, Koji Miyagawa, Hirofumi Nishikage, Masaaki Izumi, Yoshihiro Takamitsu, Association of hyperhomocysteinemia with plasma sulfate and urine sulfate excretion in patients with progressive renal disease American Journal of Kidney Diseases. ,vol. 40, pp. 909- 915 ,(2002) , 10.1053/AJKD.2002.36320
Kamil Strzelak, Jagoda Misztal, Łukasz Tymecki, Robert Koncki, Bianalyte multicommutated flow analysis system for microproteinuria diagnostics. Talanta. ,vol. 148, pp. 707- 711 ,(2016) , 10.1016/J.TALANTA.2015.04.021
Luisa Gilardini, Carolina Lombardi, Gabriella Redaelli, Luciana Vallone, Andrea Faini, Paola Mattaliano, Gianfranco Parati, Cecilia Invitti, Glucose Tolerance and Weight Loss in Obese Women with Obstructive Sleep Apnea PLOS ONE. ,vol. 8, pp. 61382- ,(2013) , 10.1371/JOURNAL.PONE.0061382
Hayet Fellah, Mohamed Bassem Hammami, Moncef Feki, Karima Boubaker, Taieb Ben Abdallah, Bernard Lacour, Abderraouf Mebazaa, Neziha Kaabachi, Predictors for cardiovascular morbidity and overall mortality in Tunisian ESRD patients: a six year prospective study. Clinical Biochemistry. ,vol. 42, pp. 648- 653 ,(2009) , 10.1016/J.CLINBIOCHEM.2008.12.023
J Loscalzo, The oxidant stress of hyperhomocyst(e)inemia. Journal of Clinical Investigation. ,vol. 98, pp. 5- 7 ,(1996) , 10.1172/JCI118776