Glutathione peroxidase of calf trabecular meshwork.
作者： L N Karageuzian , D R Scott , P J Anderson , D L Epstein
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摘要: 3 found mean levels of 26 ^M and 25 /xM in normal human bovine aqueous, respectively. Both samples showed distribution. However, a population 17 cataract patients, they highly right-skewed distribution with median value 40 compared the . They suggest that excessive H2O2 aqueous humor may impair lens membrane perme- ability contribute to formation. Since bulk leaves eye via trabecular meshwork (TM), this tissue also must be exposed these high H 2O 2. Therefore, it was interest see if TM possessed mechanism for detoxification, both protect itself more distal portions outflow system. Biochemically, is detoxified by two major en- zymatic mechanisms: one uses catalase second dienzymatic redox cycling sulfhydryl compound glutathione (GSH) peroxi- dase (GSH-Px), which catalyses reaction: + 2GSH -» 2H2O GSSG
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